Causes Of IVF Failure

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1 in 8 women need IVF in getting pregnant. If you have tried all fertility options then IVF is sometimes the right way forward, especially if you are > 35 years with multiple associated factors like sperm, egg or uterine issues.

In general, the success rate of IVF is 40-50% per attempt and it depends on various factors such as age and associated causes of Infertility.

A failed IVF cycle could be because of the poor egg quality, sperm quality, embryo quality, endometrial thickness, presence of uterine polyps, premature increase in the progesterone levels, or an infection in the uterus etc.

Some of the reasons for IVF failure are:

  • Diminished ovarian reserve which is common in women over 35 years of age. It is associated with poor ovarian stimulation response and high IVF cancellation rates.
  • Poor quality egg and sperm quality leads to poor quality embryo development which will often lead to implantation failure. Older women have poor quality eggs which will more likely to result in poor embryo quality. Poor sperm parameters can be due to genetic problem, environmental factors, lifestyle problems etc.
  • Thin endometrium will likely lead to IVF failure as it will not provide adequate blood flow and nutrients to the embryo.
  • Polycystic Ovaries leads to missed periods, irregular periods, prolonged periods, painful periods etc which leads to issues in growth and development of eggs and implantation defects.
  • Uterine factors like fibroids and polyps.
  • Tubal factors like Hydrosalpinx.
  • IVF lab factors like Oxygen concentrations, Co2 concentrations, pH, humidity, temperature, light, VOC’s etc are very important for proper growth and functioning of the embryo. Slight alterations in any may lead to embryo death and subsequently leads to IVF failure.
  • A suboptimal ovarian stimulation protocol.
  • A poor embryo transfer technique.

The obvious causes of IVF failure could be the above mentioned factors, yet even If all these causes are ruled out, still there is about 40-50% chances, that implantation may not occur the first time. The process of implantation is a very complex process consisting of millions of steps. It basically involves the embryos developing from few cells to a million cells and dividing and implanting into the uterus and uterus thereby with the help of microcapillaries sending blood and oxygen to the embryo and leading to the final implantation. Where in this complex process does the process stop or the embryos stops dividing, or does the uterus stop providing the nutrients and the blood flow is impossible to detect. This is because all is happening at a microscopic level. There are numerous tests advised for detecting the probable cause of implantation failure however each test has its advantages and disadvantages. Please see the link to check our protocol in failed IVF cycle.

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